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- Shen JP, Zhao D, Sasik R, et al. Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions. Nat Methods. 2017;14(6):573-576.
Uveal Melanoma
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PKC + MEK Combo
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- Chen X, Wu Q, Tan L, et al. Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations. Oncogene. 2014;33(39):4724-34.
- Marjon K, Cameron MJ, Quang P, et al. MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis. Cell Rep. 2016;15(3):574-587.
- Mavrakis KJ, Mcdonald ER, Schlabach MR, et al. Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5. Science. 2016;351(6278):1208-13.
- Kryukov GV, Wilson FH, Ruth JR, et al. MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells. Science. 2016;351(6278):1214-8.
- Behan FM, Iorio F, Picco G, et al. Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens. Nature. 2019;568(7753):511-516.
- Chan EM, Shibue T, Mcfarland JM, et al. WRN helicase is a synthetic lethal target in microsatellite unstable cancers. Nature. 2019;568(7753):551-556.
- Kategaya L, Perumal SK, Hager JH, et al. Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability. iScience. 2019;13:488-497.
- Lieb S, Blaha-ostermann S, Kamper E, et al. Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells. Elife. 2019;8.
- Mengwasser KE, Adeyemi RO, Leng Y, et al. Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. Mol Cell. 2019;73(5):885-899.e6.
- Ceccaldi R, Liu JC, Amunugama R, et al. Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair. Nature. 2015;518(7538):258-62.
- Mateos-gomez PA, Gong F, Nair N, et al. Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination. Nature. 2015;518(7538):254-7.
- Zhang M, Lai Y, Vasquez JL, et al. Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells. Sci Rep. 2020;10(1):3836.
- Pillay N, Tighe A, Nelson L, et al. DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors. Cancer Cell. 2019;35(3):519-533.e8.
- Leenus M, Cheng T, James DI et al. Abstract 1943: PARG inhibitors exhibit synthetic lethality with XRCC1 deficiency and a cellular mechanism of action that is distinct from PARP inhibition. Cancer Research. 2018; 78(13): Supplement.