About IDEAYA

Yujiro S. Hata

President and Chief Executive Officer

Yujiro is an entrepreneur with over 20 years of experience building companies that have delivered innovative therapies to patients. In June 2015, he launched IDEAYA Biosciences as its first employee and Chief Executive Officer and led the company’s IPO in May 2019 (NASDAQ: IDYA) and formed the partnership with GlaxoSmithKline in June 2020. From 2015 to 2018, he served as an Executive-in-Residence at 5AM Ventures. From 2014 to August 2015, he served as Chief Operating Officer at Flexus Biosciences, which he led through its acquisition by Bristol-Myers Squibb in April 2015, and then served as Chief Operating Officer at FLX Bio (renamed RAPT Therapeutics, NASDAQ: RAPT), a spinout of Flexus Biosciences. From 2010 through the approvals of Kyprolis® and Stivarga® and its acquisition by Amgen in October 2013, he was Vice President, Corporate Development and Strategy at Onyx Pharmaceuticals (NASDAQ: ONXX), where he served as Head of Strategy and Strategic Asset Management, and Head of Transactions. From 2002 to 2010, Yujiro served as Vice President, Business Development, Senior Vice President, Business Development, and Chief Business Officer at Enanta Pharmaceuticals (NASDAQ: ENTA), which discovered the protease inhibitors contained in Viekira Pak and Mavyret™, both of which received Breakthrough Therapy designation and approval by the FDA. He earlier served in roles at McKinsey, ImClone and Columbia Medical School.

Yujiro obtained his M.B.A. at the University of Pennsylvania, his B.A. in chemistry at Colorado College, and did undergraduate studies in chemistry and biology at Oxford University. He serves on the Board of Directors at Xencor (NASDAQ: XNCR) and Expansion Therapeutics, and Board of Visitors at the Moores Cancer Center at the University of California, San Diego.

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Michael P. Dillon, Ph.D.

Senior Vice President and Chief Scientific Officer, Head of Research

Mike brings over 20 years of experience in drug discovery. He joined IDEAYA Biosciences as Senior Vice President, Head of Drug Discovery in April 2016, and has served as Senior Vice President and Chief Scientific Officer, Head of Research since February 2018. From 2008 to 2016, Mike was with the Novartis Institutes for Biomedical Research (NIBR) where he served in various leadership roles, including Global Discovery Chemistry Head, Oncology and New Therapeutic Modalities; Head of Chemical Sciences, Emeryville, and Executive Director Oncology Chemistry. Under his leadership at NIBR, several small molecules were advanced towards the clinic, including, PI3K inhibitor BKM120, CSF1R inhibitor BLZ945, V600E mutant B-RAF kinase inhibitor Encorafenib, PIM kinase inhibitor PIM447, ERK inhibitor LTT462, and RAF kinase inhibitor LXH254. From 1993 to 2008, Mike worked at Roche and Syntex (acquired by Roche), where he served in roles of increasing responsibility, including Director, Medicinal Chemistry. At Roche, he led multiple small molecule programs that advanced to the clinic, including first-in-class P2X3 antagonist Gefapixant, now being developed by Merck. Mike is an author on over 60 publications and patents.

Mike obtained his B.Sc. (Hons) from the University of Leicester, and his Ph.D. in Chemistry from the University of Bristol. He completed his postdoctoral fellowship at Oregon State University to continue his research in Chemistry with Professor James D. White.

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Mark Lackner, Ph.D.

Senior Vice President, Head of Biology and Translational Sciences

Mark has nineteen year’s experience in oncology drug development with broad experience ranging from target identification through biomarker development in registrational clinical trials. He is Vice President and head of Biomarkers and Synthetic Lethal Biology at IDEAYA. Prior to joining IDEAYA, Mark worked at Genentech for 14 years in positions of increasing responsibility in the Oncology Biomarker Development group, most recently as a Director and Principal Scientist. At Genentech his group was accountable for predictive and pharmacodynamic strategies for candidate therapeutics spanning cancer signaling through immuno-oncology, and was accountable for clinical biomarker strategies for over 20 development stage small molecule and antibody agents. His group developed clinical biomarker strategies for immune doublet combinations with the anti-PDL1 antibody Tecentriq, as well as phase III companion diagnostic strategies for the AKT inhibitor Ipatasertib and the MEK and BRAF inhibitors Cobimetinib and Vemurafenib. Mark also provided strategic leadership for the overall breast cancer biomarker strategy within the broader Roche organization. Prior to joining Genentech, Mark worked at Exelixis (NASDAQ: EXEL) from 1999 through 2004 in oncology target identification and validation, including the identification of synthetic lethal interactions with the tumor suppressor gene p53.

Mark received his PhD from Stanford University in 1997 for studies on genetic analysis of RAS/MAP kinase signaling. He completed postdoctoral studies at UC Berkeley in the laboratory of Joshua Kaplan. He has authored over 55 peer reviewed scientific manuscripts in journals including Nature Medicine, Nature Communications, Journal of Clinical Oncology, Cancer Cell and Clinical Cancer Research.

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Paul A. Stone, J.D.

Senior Vice President and Chief Financial Officer

Paul is a life science executive with over 20 years of legal, financial, and management experience. Paul was previously with 5AM Ventures for over nine years in various leadership capacities including as Partner, General Counsel, and Chief Operating Officer. Paul serves as a Board of Director of Scientist.Com and was a founding Director at Cidara (NASDAQ: CDTX), Homology (NASDAQ: FIXX), and IDEAYA (NASDAQ: IDYA), as well was a Board Observer at RareCyte and other companies. He also held early management and operating rolls at Cidara, Entrada, IDEAYA and Homology. Prior to joining 5AM, Paul was Senior Vice President and General Counsel at Ethos Pharmaceuticals, Senior Vice President, General Counsel and Chief Patent Counsel at Ilypsa (acquired by Amgen) and Vice President, Chief Patent Counsel at Symyx (IPO). He earlier served in roles at Boeing and Wisconsin Electric.

Paul earned a B.S. in Chemical Engineering, University of Wisconsin, Madison, after which he served as a U.S. Naval Officer on USS NIMITZ. He received a J.D. from University of Wisconsin Law School and practiced intellectual property law as a Patent Attorney at Senniger Powers. Paul taught patent law, trade secrets law and licensing as an adjunct professor at University of Missouri and Santa Clara University. He also served on the Board of Directors of a regional non-profit, Save the Bay.

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Jason S. Throne, J.D.

Senior Vice President, General Counsel

Jason has over 20 years of legal experience representing both public and private life sciences companies. He joined IDEAYA Biosciences as Vice President, General Counsel in October 2019. Prior to joining IDEAYA Biosciences, Jason served as Vice President, General Counsel of NeoTract, Inc., a urology medical device company, until its acquisition by Teleflex Incorporated. Prior to NeoTract, Jason held various roles, including Associate General Counsel, Corporate & Compliance Officer, at Thoratec Corporation (NASDAQ: THOR), a cardiology medical device company, which was acquired by St. Jude Medical. Previously, Jason was an associate at the law firm of Cooley Godward LLP, representing both private and public companies on corporate matters, and a senior audit accountant at the accounting firm of Deloitte & Touche LLP.

Jason earned a J.D. from the University of Virginia School of Law and a B.S. in Business from the University of Colorado.

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Paul A. Barsanti, Ph.D.

Vice President, Head of Drug Discovery

Paul brings over 20 years of drug discovery experience. He joined IDEAYA Biosciences as Vice President, Head of Drug Discovery in July 2019. Prior to that he was an Executive-in-Residence at 5AM Ventures where he was involved with several early seeded new companies. From 2014 to 2018 Paul served as Head of Chemistry at Nurix, Inc., where he built and led the Chemical Sciences department and helped develop first in class small molecules against novel E3 ligases for therapeutic use within the fields of oncology and immuno-oncology. This includes the advancement of Nurix’s small molecule Cbl-b inhibitor. He played a pivotal role in initiating Nurix’s entry into their DEL and PROTAC technology platforms, enabling a protein degradation therapeutic pipeline which includes Nurix’s BTK degrader currently in pre-clinical development. From 2006 to 2014, Paul worked at the Novartis Institutes for Biomedical Research (NIBR) where he served in various leadership roles including, Oncology Group Leader, Medicinal Chemistry where he and his teams focused on delivering best in class clinical candidates to treat cancer patients, including the RAF kinase inhibitor LHX254. Prior to Novartis, Paul worked in the fields of oncology and infectious diseases at Chiron Corporation (acquired by Novartis).

Paul is an author on over 50 publications and patents. Paul obtained both his Chemistry B.Sc. (Hons) and his Ph.D. in Organic Chemistry from the University of Bath. He completed his postdoctoral fellowship at the University of Illinois at Urbana-Champaign with Professor Scott E. Denmark.

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Mick O’Quigley

Vice President, Development Operations

Mick has over 20 years of clinical research experience across all phases of oncology drug development. As Vice President, Development Operations, Mick is currently responsible for the oversight of the execution of IDEAYA’s clinical pipeline. Prior to joining IDEAYA, Mick served as a Program Group Director in clinical operations at Genentech’s Research and Early Development group from January 2008 to June 2018 years where he was responsible for multiple immuno-oncology programs. Mick led the initiation and operational implementation of a global network of leading immuno-oncology institutions to accelerate clinical research across the Roche-Genentech pipeline. Prior to joining Genentech, Mick worked at Amgen from 1996 to 2008 where he held roles of increasing clinical development responsibilities for multiple products, including Aranesp^®, Kepivance^® and Vectibix^®. Mick also held earlier roles at Rhône-Poulenc Rorer and PAREXEL.

Mick earned his M.B.A. from Pepperdine University and his B.A. from Trinity College Dublin.

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Julie Patel

Vice President, Human Resources

Julie has extensive experience as a human resources professional, with 25 years of life sciences experience at world-class biopharmaceutical companies. She joined IDEAYA in April, 2020 as Vice President, Human Resources, and has broad functional responsibility, including talent acquisition, leadership development and shaping the employee experience, people capabilities and culture. Prior to joining IDEAYA, Julie previously served at Jazz Pharmaceuticals as a Senior Director, HR Business Partner for US Commercial Sales and Marketing, Global Legal and Compliance, and earlier as a Director of Learning and Development. Prior to Jazz, Julie was Senior Director, Strategic HR, Global Development at Elan Pharmaceuticals. Julie also worked earlier in her career at Johnson & Johnson companies ALZA and Scios in human resource business partner roles for research and development, as well as led the recruiting, employee relations, and talent management functions.

Julie earned her B.A. in Information and Communications Studies at California State University, Chico, holds certifications in numerous training and development programs, and attended executive coaching through Fielding Graduate University. She also currently serves as a mentor with the Healthcare Business Women’s Association in San Francisco.

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Andres Ruiz Briseno, C.P.A.

Vice President, Finance

Andres has 10 years of progressive accounting and finance experience for public and private life science companies. He joined IDEAYA Biosciences as Controller in August 2016 and has served as Vice President, Finance since July 2019. Prior to joining IDEAYA, Andres served as Associate Director of Financial Planning & Analysis at Pharmacyclics, Inc. (NASDAQ: PCYC), where he helped lead the organization’s finance and operations efforts in support of the successful launch of blockbuster cancer drug, IMBRUVICA^® (ibrutinib). He also played a key role in building the Company’s long-range planning and the integration activities into AbbVie, following Pharmacyclics’ $21 billion acquisition. Previously, Andres held roles at Theravance, Inc. (NASDAQ: THRX) and at PricewaterhouseCoopers’ audit and assurance practice where he focused on life science and venture capital clients.

Andres obtained his B.S. in Business Administration with a concentration in Corporate Financial Management from San Jose State University and is a Certified Public Accountant, licensed in the state of California.

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Alan D. D'Andrea, M.D.

Chair of IDEAYA SAB | Professor, Harvard Medical School and Member, National Academy of Medicine

Alan D’Andrea, M.D. is the Fuller-American Cancer Society Professor of Medicine at Harvard Medical School and the Director of the Center for DNA Damage and Repair at the Dana-Farber Cancer Institute in Boston. His research is focused on the identification of genetic vulnerabilities in human cancers including leukemia, ovarian, and breast cancer. Dr. D’Andrea is a member of the Board of Scientific Counselors of the National Cancer Institute and is a recipient of the G.H.A. Clowes Award from the American Association of Cancer Research. He currently co-leads the Stand up to Cancer Ovarian Cancer Dream Team with Dr. Elizabeth Swisher.

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Brian Daniels, M.D.

Director | Former SVP, Global Development and Medical Affairs, Bristol-Myers Squibb

Brian Daniels, M.D., served as Senior Vice President of Global Development and Medical Affairs and Research and Development of Bristol-Myers Squibb Co. from March 2008 to July 1, 2014. He served as Senior Vice President of Global Clinical Development, Research and Development of Bristol-Myers Squibb Co. from 2004 to 2008. He also served as a Member of Management Council at Bristol-Myers Squibb Company. He held positions directing and conducting clinical research at Merck and Genentech. He directed the development of innovative medicines, including Apixaban®, Onglyza®, Myalept® and Farxiga® (CV/metabolics), Orencia® and Nulogix® (immunology), Abilify®(neuroscience), Baraclude®, Reyataz®, Daclatasvir® and Asunaprevir® (virology) and Sprycel®, Ixempra®, Yervoy®, elotuzumab and nivolumab (oncology). He serves on the Board of Directors of Novo Nordisk, among others. He completed residency programs at The New York Hospital of Cornell Medical College and at UCSF. Dr. Daniels has an M.D. from Washington University and an M.S. and B.S. from MIT.

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Jeffrey Hager, Ph.D.

Jeff is a San Diego-based biopharma consultant with over 20-years of experience in tumor biology, cancer pharmacology, & oncology discovery. Before joining the IDEAYA Biosciences SAB, he was Senior Vice President and Chief Technology Officer and Head of Target Discovery and External Innovation at IDEAYA Biosciences. Prior to that he was Senior Vice President and Head of Biology at IDEAYA. Before his involvement with IDEAYA, he was VP of Biology at Seragon Pharmaceuticals, which was acquired by Roche/Genentech, where he oversaw all in vitro and in vivo biology and pharmacology that lead to the discovery of 2 novel, clinical stage selective estrogen receptor degraders (SERDs) developed as treatment for hormone receptor positive breast cancer. Previously, Jeff was Senior Director at Aragon Pharmaceuticals which was acquired by Johnson & Johnson. At Aragon, his team was central in pre-clinical development of the novel anti-androgen apalutamide (Erleada™), an FDA approved treatment for early-stage castration resistant prostate cancer. Previously, he was Associate Director of Biology at Apoptos, Inc. and before that a Principal Scientist and Head of Cancer Pharmacology at Kalypsys, Inc.

He did graduate studies at Princeton and University of California at Berkeley, the later from which he received a PhD in molecular and cell biology. He was a postdoctoral fellow and staff scientist at the University of California at San Francisco and is an author of publications in Annual Review of Cancer Biology, eLife, Science, Nature Genetics, Cancer Cell, Cancer Research and Cancer Discovery.

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Trey Ideker, Ph.D.

Professor, University California at San Diego

Trey Ideker, Ph.D., is a Professor in Medicine, Bioengineering and Computer Science at UCSD; Co-Director of the Cancer Genomes and Networks Program at UCSD Moores Comprehensive Cancer Center, and Director of the San Diego Center for Systems Biology. His lab develops technology to build molecular network maps of the cell and to use these networks to translate genotype to phenotype in cancer. He has founded influential bioinformatic tools including Cytoscape, a popular network analysis platform which has been cited >12,000 times. Ideker serves on the Editorial Boards for Cell, Cell Reports, Molecular Systems Biology, and PLoS Computational Biology and is a Fellow of AAAS and AIMBE. He was named one of the Top 10 Innovators of 2006 by Technology Review magazine and was the recipient of the 2009 Overton Prize from the International Society for Computational Biology.

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Frank McCormick, Ph.D., FRS, DSc (Hon)

Professor, University of California at San Francisco

Dr. McCormick is a Professor in the University of California, at San Francisco (UCSF), Helen Diller Family Comprehensive Cancer Center and holds the David A. Wood Chair of Tumor Biology and Cancer Research at UCSF. Prior to joining UCSF, Frank was Founder and Chief Scientific Officer at Onyx Pharmaceuticals, building on his earlier research and leadership experiences at Cetus and Chiron. At Onyx, initiated and led drug discovery efforts that led to the approval of Sorafenib for treatment of renal cell cancer and liver cancer. Dr. McCormick has served as President of the American Association for Cancer Research (AACR) and has a leadership role at the Frederick National Lab for Cancer Research, overseeing an NCI supported national effort to develop therapies against Ras-driven cancers.

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William R. Sellers, M.D.

Core Institute Member, Broad Institute, Dana-Farber Cancer Institute, and Harvard Medical School

Dr. Sellers is a Core Institute Member at the Broad Institute and faculty member of the Dana-Farber Cancer Institute and Harvard Medical School. From 2005-2016, Dr. Sellers directed cancer drug discovery and early cancer clinical development at the Novartis Institutes for BioMedical Research, during which the oncology research group brought more than 30 cancer therapeutics into first-in-man trials including therapeutics targeting the PI3K, CDK4, IDH, ABL, SMO, HER3, ALK, Wnt, PIM and Ras pathways among others. Along with Dr. Carl June, he co-chaired the CART collaboration with the University of Pennsylvania that brought CTL019 to a recent FDA approval.

Prior to Novartis, Dr. Sellers was an Associate Professor of Medicine at the Dana-Farber Cancer Institute and Harvard Medical School and an Associate Member of the Broad Institute where he initiated large-scale projects which led to discovery of EGFR mutations in lung adenocarcinoma and the discovery of the oncogenic role of the MITF gene in melanoma. In addition, his work advanced the understanding of the molecular mechanisms of growth regulation of the PTEN tumor suppressor gene. Dr. Sellers was a member of the National Cancer Advisory Board from 2011 to 2016. Dr. Sellers received his B.S. from Georgetown University in 1982 and M.D. from the University of Massachusetts Medical School in 1986. He completed residency training in Internal Medicine at the University of California San Francisco in 1989 and trained in Medical Oncology at the Dana-Farber Cancer Institute.

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Elizabeth Swisher, M.D.

Professor, University of Washington

Elizabeth Swisher, M.D., is a gynecologic oncologist, Professor of Gynecologic Oncology, and adjunct Professor of Medical Genetics at the University of Washington in Seattle. Dr. Swisher’s research focused on understanding the role of the BRCA-Fanconi anemia pathway in ovarian cancer and how defects in DNA repair can be exploited in the therapy and prevention of ovarian carcinoma. She is co-Leader of Stand up to Cancer’s first Ovarian Cancer Dream Team. She is principal investigator on several PARP inhibitor therapeutic trials and collaborates on the translational research for numerous other clinical trials in ovarian and other cancers.

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Timothy Shannon, M.D.

Chairman of the Board | General Partner, Canaan Partners

Timothy Shannon, M.D., is a General Partner at Canaan Partners where he focuses on early stage biopharmaceutical companies. He is chairman of the board of Arvinas and Spyryx Therapeutics and is a director at NextCure, Vivace, and CytomX (CTMX, IPO 2015). Prior successful companies include Civitas Theraputics (acquired by Acorda) and Novira Therapeutics (acquired by Johnson & Johnson). Dr. Shannon previously was president and chief executive officer of CuraGen, a publically traded biopharmaceutical company. CuraGen merged with Celldex Therapeutics in 2009 where Dr. Shannon served on the board. Prior to that he was senior vice president of global medical development for Bayer’s Pharmaceutical Business Group. Dr. Shannon began his career as an assistant professor of pulmonary and critical care medicine at Yale University School of Medicine, received his M.D. from the University of Connecticut, and his B.A. from Amherst College.

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Garret Hampton, Ph.D.

Director | President, Clinical Sequencing and Oncology, ThermoFisher Scientific

Garret Hampton, Ph.D., is currently President, Clinical Sequencing and Oncology at ThermoFisher Scientific, responsible for leading the company’s clinical next generation sequencing strategy. Prior to ThermoFisher, Garret was Senior Vice President, Clinical Genomics, at Illumina, responsible for the development of sequencing-based solutions in oncology, reproductive health and whole genome sequencing for the diagnosis of rare disease. Before joining Illumina, Garret held a variety of leadership positions at Genentech / Roche; Celgene, and The Genomics Institute of the Novartis Research Foundation, focused on drug target discovery, drug development and precision medicine. Before moving into industry, Garret was Assistant Professor of Medicine at UCSD, San Diego after a 2-year postdoctoral fellowship at the Salk Institute for Biological Studies. Hampton received his Ph.D. from the Imperial Cancer Research Fund (now Cancer Research UK) under Sir Walter Bodmer. He has authored over 150 peer reviewed articles and reviews, with 10,000 lifetime citations.

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Scott Morrison

Director | Partner, Ernst & Young (retired)

Mr. Morrison has served as a member of IDEAYA's board of directors since July 2018. He had a 35-year career in public accounting, serving public and private companies in the life sciences sector. Mr. Morrison was a partner at Ernst & Young LLP and served as its U.S. Life Sciences Leader until his retirement in 2015. He has worked on hundreds of public and private financings, M&A transactions and corporate collaborations. Mr. Morrison currently serves on the board of directors and chairs the audit committees of Audentes Therapeutics, Corvus Pharmaceuticals, Global Blood Therapeutics and Symic Bio. He has served on numerous life sciences industry boards, including the Biotechnology Innovation Organization (BIO) ECS Board, the Bay Area Bioscience Center, the California Life Sciences Foundation, and the Biotechnology Institute. Mr. Morrison holds a B.S. in business administration from the University of California, Berkeley. He is a certified public accountant (inactive).

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Terry Rosen, Ph.D.

Director | Chief Executive Officer, Arcus Biosciences

Terry Rosen, Ph.D. is currently the CEO of Arcus Biosciences. He previously served as CEO of Flexus Biosciences, which was acquired by BMS in 2015. Prior to co-founding Flexus in October of 2013, Terry served as Vice President, Therapeutic Discovery (TD) at Amgen and as the site head for Amgen South San Francisco, having joined Amgen with the acquisition of Tularik in 2004. Terry held several executive positions at Tularik, including Executive Vice President, Operations, Vice President, Research Operations, and Vice President, Medicinal Chemistry. He has also held scientific and management positions at Pfizer and Abbott Laboratories. Terry serves on the Salk Institute Board of Trustees, the leadership committees of the University of Michigan Undergraduate Research Opportunity Program and Life Sciences Institute, the Berkeley Chemistry Advisory Board, the Caltech Biology and Biology and Biological Engineering Chair’s Council and the California Life Sciences Association Board. He holds a B.S. in Chemistry from the University of Michigan and a Ph.D. in Organic Chemistry from the University of California, Berkeley.

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Jeffrey Stein, Ph.D.

Director | President and Chief Executive Officer, Cidara Therapeutics

Jeffrey Stein, Ph.D., has been the President and Chief Executive Officer of Cidara Therapeutics since 2014. Prior to joining Cidara, Dr. Stein was Chief Executive Officer of Trius Therapeutics from its founding in 2007 until its acquisition by Cubist Pharmaceuticals in September of 2013. Dr. Stein was also the founding Chairman and President of the Antibiotics Working Group. Previously, Dr. Stein was a Venture Partner and Kauffman Fellow with Sofinnova Ventures and opened the firm's San Diego office in 2005. Prior to joining Sofinnova, Dr. Stein was co-founder and Chief Scientific Officer of Quorex Pharmaceuticals which was acquired by Pfizer Pharmaceuticals in 2005. He has also served as a Principal Scientist with Diversa Corporation and the Agouron Institute. Dr. Stein conducted his postdoctoral research as an Alexander Hollaender Distinguished Postdoctoral Fellow at the California Institute of Technology and his graduate work as a NASA Graduate Student Researcher Fellow at UCSD.

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Wendy Yarno

Director | Former Executive Vice President and Chief Marketing Officer, Merck & Co.

Ms. Yarno spent 26 years at Merck & Co. in commercial and human resource positions of increasing seniority, including most recently as Executive Vice President and Chief Marketing Officer. She previously served as General Manager, Cardiovascular / Metabolic U.S. Business Unit and as Executive Vice President, Worldwide Human Health Marketing. In these roles, Ms. Yarno developed deep expertise in pharmaceutical commercialization, including drug development, regulatory strategy, market development, global product strategy and product life-cycle management. Ms. Yarno currently serves on the board of directors of publicly traded life sciences companies Global Blood Therapeutics, Inovio Pharmaceuticals, Inc. and Myokardia. She previously served on the board of directors of various other life science companies, including Alder Biopharmaceuticals, Durata Therapeutics, St. Jude Medical and Medivation.

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GlaxoSmithKline

IDE397 (MAT2A), Pol Theta, Werner Helicase

IDEAYA and GSK entered into a broad strategic partnership in Synthetic Lethality. The partnership covers three IDEAYA Synthetic Lethality programs – MAT2A, Pol Theta and Werner Helicase. The companies have highly complementary Synthetic Lethality pipelines that enable strategic combination opportunities.

June 2020 Announcement

Pfizer Inc.

IDEAYA and Pfizer have established a clinical trial collaboration and supply agreement, pursuant to which Pfizer will supply binimetinib, a MEK inhibitor, and crizotinib, a cMET inhibitor, in support of an ongoing IDEAYA-sponsored Phase 1/2 clinical trial evaluating IDE196 in combination with binimetinib, and in a separate arm of the clinical trial, in combination with crizotinib, in each case in patients harboring GNAQ or GNA11 mutated solid tumors, including in metastatic uveal melanoma.

March 2020 Announcement
September 2020 Announcement

Cancer Research UK / University of Manchester

IDEAYA has established a strategic research collaboration with the Drug Discovery Unit at Cancer Research UK (CRUK) and the University of Manchester related to IDEAYA’s Poly(ADP-ribose) glycohydrolase (PARG) program. IDEAYA controls all commercial rights in its PARG program.

March 2020 Announcement

University of California San Diego

Synthetic Lethality Target Identification

IDEAYA is collaborating with Dr. Trey Ideker PhD, Professor of Medicine and Bioengineering, UCSD, on combinatorial CRISPR screens of key nodes of the DNA damage and repair pathway and human tumor suppressor genes to identify next generation synthetic lethality targets.

Broad Institute

Biomarker and Translational Research

IDEAYA is member of the Broad Institute’s DepMap Consortium, enabling access to genome-wide screens of cell lines based on single CRISPR gene editing. We are also collaborating with Dr. Bill Sellers, M.D., a core institute member of the Broad Institute, and faculty member at Harvard Medical School and at Dana-Farber Cancer Institute. Our collaborative research aims are directed to identifying and validating synthetic relationships, including through the Broad’s dual sgRNA knock-down paralog screens to identify targets having functional redundancies.

October 2020 Announcement

University of California San Francisco

Biomarker and Translational Research

IDEAYA is engaged in collaborative research with Dr. Sourav Bandyopadhyay, PhD, an Associate Professor in the Department of Bioengineering and Therapeutic Sciences of the Helen Diller Family Comprehensive Cancer Center at UCSF, to identify and validate biomarker-enabled synthetic lethal relationships.

Novartis Institute for Biomedical Research (NIBR)

IDE196 (PKC)

IDEAYA has an exclusive license with Novartis International Pharmaceutical Ltd. pursuant to which IDEAYA is developing and commercializing IDE196, a potent, small molecule protein kinase C (PKC) inhibitor for the treatment of cancers having GNAQ and GNA11 mutations. IDEAYA controls all commercial rights in its PKC program.

October 2018 Announcement