Novartis Institute for Biomedical Research (NIBR)
IDEAYA has an exclusive license with Novartis International Pharmaceutical Ltd. pursuant to which IDEAYA is developing and commercializing IDE196, a Phase 1 protein kinase C (PKC) inhibitor for the treatment of cancers having GNAQ and GNA11 mutations. IDE196 is a potent small molecule inhibitor of PKC demonstrating early clinical activity and tolerability in a Phase 1 clinical trial conducted by Novartis Institute for Biomedical Research. IDEAYA is conducting an ongoing Phase 1/2 clinical basket trial, and has exclusive rights for further clinical development of IDE196, together with unrestricted rights to commercialize worldwide.
IDEAYA entered into a clinical trial collaboration and supply agreement with Pfizer Inc., pursuant to which Pfizer will supply IDEAYA with their MEK inhibitor, binimetinib, for an IDEAYA sponsored clinical combination study of IDE196 and binimetinib in GNAQ or GNA11 hotspot mutated solid tumors, including Metastatic Uveal Melanoma, Cutaneous Melanoma, and Colorectal Cancer. IDEAYA and Pfizer will form a Joint Development Committee (JDC), and there will be joint decision making and data sharing of the clinical trial results between the parties.
Boston Children’s Hospital
IDEAYA entered into a sponsored research agreement with Boston Children’s Hospital for preclinical evaluation of the role of protein kinase C (PKC) in Sturge Weber syndrome (SWS), a rare neurocutaneous disorder characterized by capillary malformations and associated with mutations in GNAQ. Under the agreement, IDEAYA will collaborate with and support research at Boston Children’s Hospital in the laboratory of Dr. Joyce Bischoff, Ph.D., Research Associate, Department of Surgery and Professor, Harvard Medical School, who is Principal Investigator of the research studies.
Cancer Research UK / University of Manchester
IDEAYA has established a partnership with the Drug Discovery Unit at Cancer Research UK (CRUK) and the University of Manchester related to its Poly(ADP-ribose) glycohydrolase (PARG) program. Under this arrangement, IDEAYA has rights for development and commercialization of PARG inhibitors worldwide.
University of California San Diego
Building a sustainable pipeline of high value synthetic lethality based oncology programs is central to the IDEAYA mission. To compliment the internal efforts around target identification and validation we have an ongoing collaboration with Dr. Trey Ideker PhD Professor of Medicine and Bioengineering, UCSD. Dr. Ideker is a recognized leader in combining functional genomics and computational methods to understand gene-gene and pathway interactions at a “systems” level. Under a collaborative agreement, the Ideker Lab and IDEAYA are carrying out combinatorial CRISPR screens of key nodes of the DNA damage and repair pathway and human tumor suppressor genes, to identify next generation druggable synthetic lethality targets.
University of California San Francisco
IDEAYA is engaged in collaborative research with UCSF, which forms part of its strategic network for discovery and validation of biomarkers. Dr. Sourav Bandyopadhyay, PhD, is an Associate Professor in the Department of Bioengineering and Therapeutic Sciences of the Helen Diller Family Comprehensive Cancer Center at UCSF. Dr. Bandyopadhyay and IDEAYA are collaborating to identify and validate novel synthetic lethal relationships.