Targeted therapies are based on an enhanced understanding of tumor biology, such as genomic mutations that drive cell proliferation.
An understanding of tumor biology, in particular genomic mutations that drive cell proliferation, enables an opportunity to target oncogenic pathways for cancers with limited or no effective treatments. IDEAYA is pursuing small molecule therapeutics with step-change impact for patients with genetically defined tumors.
Targeted therapies are particularly effective for selective targeting of a target protein / enzyme which is specific to the cancer biology for a particular tumor type. As such, integration of biomarker-enabled translational approach for identifying patients most likely to respond to a particular therapy is paramount for targeted therapy approaches.